Tumor lysis syndrome

Introduction. Tumor lysis syndrome is an emergency condition requiring prompt recognition and treatment. It?s a consequence of spontaneous or therapy-induced cellular death leading to the release intracellular ions metabolic products purine bases into bloodstream. Pathophysiology. The characteristic derangement comprises hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia. These changes can lead kidney failure, arrhythmia, seizures. Epidemiology, classification risk assessment. incidence tumor varies between different types tumors, but it most common in hematologic malignancies. According Cairo - Bishop Classification, be defined as laboratory clinical syndrome. Preventive measures treatment Frequent monitoring obligatory patients with intermediate high are based on vigorous hydration administration medication control serum uric acid levels. When develops, additional treatment, including renal replacement therapy, needed for correction disturbances. Conclusion. potentially fatal complication suffering from Early at prophylactic therapeutic improves outcomes these patients.